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Home » Products » Zobrixol
Ambroxol
Zobrixol®
FORMULATION:
Each Zobrixol tablet contains. 30mg Ambroxol HCl
Each 5mL Zobrixol DS . 30mg Ambroxol HCl
Each 5mL Zobrixol Syrup contains . 15mg Ambroxol HCl
Each mL Zobrixol Infant drops contains.6mg Ambroxol HCl
INDICATIONS:
Acute and chronic disorders of the respiratory tract with pathology increased mucus viscosity, such as acute and chronic bronchitis, asthmatoid bronchitis, bronchial asthma with disturbances of secretion elimination, bronchiectasis and to encourage elimination of phlegm during inflammation of the nasal cavity and throat.
ACTION:
Zobrixol is a secretolytic. It causes the formation of qualitatively different mucus of lower viscosity by the mucus-secreting cells and thus leads to a liquefaction of the mucus in the lumen of the respiratory tract. Expectoration of mucus is facilitated and breathing is eased considerably.
Long term used is possible because of the good tolerability of the preparation.
PHARMACOKINETICS:
Zobrixol is completely absorbed after oral administration. It reaches maximum plasma concentration 9 to 10 hours. The therapeutically effective plasma levels are slightly higher than 30mg/mL and can be achieved by 2 x 30mg/day orally (minimum steady state concentration approximately 50mg/mL).
Zobrixol is changed into various metabolites, which are mainly eliminated as water-soluble conjugates. After oral administration, 85% of the active substance is eliminated in the urine. Less than 10% is eliminated in the form of unchanged Zobrixol.
CONTRAINDICATION:
Although no evidence has been obtained (even at high dosage levels) of teratological activity, as with any preparation, administration is not recommended during the first three month of pregnancy.
ADVERSE REACTIONS:
Gastro-intestinal disturbances, transient rise in serum aminotransferase. In rare cases weakness, headache and skin rash.
INTERACTIONS:
Zobrixol should not be taken simultaneously with antitussive (e.g. codeine), because it could lead to non-expectoration of phlegm or mucus previously liquefied by Zobrixol.
CAUTION:
Foods, Drugs, Devices and Cosmetics Acts prohibits dispensing without prescription.
DOSAGE AND ADMINISTRATION:
TABLET (30mg)
Children 6 - 12 years : ½ tablet 2-3 times daily.
Adult & Children over 12 years : 1 tablet thrice a day for the first 2-3 days and then 1 tablet twice a day or ½ tablet thrice a day.
DOUBLE STRENGTH SYRUP (30mg /5mL)
Children 6 - 12 years: 2.5mL 2 - 3 times a day
Adult & Children over 12 years : 5mL thrice a day for 2-3 days then 5mL twice daily for 2.5mL thrice a day.
SYRUP
Children under 2 years : 2.5mL twice a day
Children 2 - 5 years : 2.5mL thrice a day
Children 6 - 12 years : 5mL 2-3 times a day
Adults & children over 12 years : 10mL thrice daily during the first 2-3 days, then 10mL twice daily or 5mL thrice daily.
INFANT DROPS (6mg/mL)
Children 6 months and under : 0.5mL twice a day
Children 7-12 months : 1mL twice a day
Children 13-24 months: 1.25mL twice a day
AVAILABILITY:
30mg tablet : Box of 100's
30mg/5mL DS : Bottle of 60mL
15mg/5mL Syrup: Bottle of 60mL
6mg/mL infant drops : Bottle of 15mL
ALSO AVAILABLE:
75mg Sustained-release Capsule : Box of 50's
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