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Apotex
[Patriot]
Regulatory Class: Rx
C: Clopidogrel bisulfate
I: Prevention of atherosclerotic events in peripheral arterial disease, or w/in 35 days of MI, or w/in 6 mth of ischemic stroke, or in acute coronary syndrome w/o ST-segment elevation.
D: Prophylaxis of thromboembolic events 75 mg once daily. Management of acute coronary syndromes including unstable angina & non-Q wave MI Single 300 mg loading dose followed by 75 mg daily.
AR: Dyscrasias. Serum sickness, interstitial pneumonitis, erythema multiforme, Stevens-Johnson syndrome, lichen planus, myalgia (rarely). Should be stopped 5-7 days before elective surgery.
INT: Increase risk of bleeding w/ anticoagulants, antiplatelets & NSAIDs. Reduce the conversion of bupropion to its active metabolite. Myopathy & rhabdomyolysis in patients receiving ciclosporin w/ statins (atorvastatin, lovastatin or simvastatin).
