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Home » Products » Kidz Kit 3
Pyrazinamide
Zcure®
250mg/5mL
Suspension
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Rifampicin
Natricin® Forte
200 mg/5 mL
Suspension
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Isoniazid + Pyridoxine HCl
Curazid® Forte
200 mg/10mg per 5mL
Syrup
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KIDZ KIT 3®
Anti-tuberculosis
PRESENTATION:
Each pack of Kidz Kit 3 contains:
2 - 120mL bottles of Zcure 250mg per 5mL suspension
1 - 120mL bottle of Natricin Forte 200mg per 5mL suspension
1 - 120mL bottle of Curazid Forte 200mg/10 mg per 5mL syrup
FORMULATION:
Each 5mL of Zcure suspension contains 250mg pyrazinamide
Each 5mL of Natricin Forte suspension contains 200mg rifampicin
Each 5mL of Curazid forte syrup contains 200mg isoniazid and 10mg pyridoxine
hydrochloride (Vitamin B6)
INDICATIONS:
For the treatment of pulmonary and extrapulmonary tuberculosis.
PRECAUTIONS:
Pyrazinamide is contraindicated in patients with liver damage, but if treatment is necessary, the dosage must be reduced. Liver function should be assessed before and regularly during treatment. Pyrazinamide should not be given to patients with acute gout or hyperuricaemia and should be used with caution in patients with a history of gout. Caution should be observed in patients with impaired renal function. Increased difficulty has been reported in controlling diabetes mellitus when diabetics are given pyrazinamide.
Liver functions should be checked before treatment with rifampicin and special care should be taken in alcoholic patients or those with pre-existing liver disease who require monitoring during therapy. When other liver function tests are within normal limits, hyperbilirubinaemia in the first weeks or moderately elevated alkaline phosphatase are not indications to withdraw rifampicin. However, dose adjustments are necessary when there is other evidence of more serious liver toxicity. It is contraindicated in patients with jaundice or hypersensitivity with rifampicin.
Isoniazid should be administered with caution to patients with convulsive disorders, a history of psychosis or hepatic or renal dysfunction. Patients who are at risk of neuropathy or pyridoxine deficiency, including those who are diabetic, alcoholic, malnourished, uraemic, pregnant or infected with HIV, should receive pyridoxine usually in a dose of 10mg daily. Although some have suggested using 50mg daily. If symptoms of hepatitis such as malaise, fatigue, anorexia and nausea develop, isoniazid should be discontinued pending evaluation.
Periodic eye examinations during isoniazid treatment have been suggested.
Liver function should be assessed before and regularly during treatment of these anti-tuberculosis drugs.
ADVERSE EFFECTS:
Hepatoxicity is the most serious side effect of pyrazinamide therapy and its frequency appears dose related. However, in currently recommended dose, when given with isoniazid and rifampicin, the incidence of hepatitis has been reported to be less than 3%. Hyperuricaemia commonly occurs and may lead to attacks of gout.
Rifampicin is usually well tolerated. Adverse effects are more common during intermittent therapy or restarting interrupted treatment. Gastrointestinal adverse effects include nausea, vomiting, anorexia and epigastric distress. Administration on an empty stomach is recommended for maximal absorption, but this has to be balanced against administration after a meal to minimize gastrointestinal intolerance. Pseudomembranous colitis has been reported. Rifampicin produces transient abnormalities in liver functions. Rifampicin causes a harmless orange-red discoloration of the urine and other body fluids.
Isoniazid is generally well tolerated at currently recommended doses. Patients who are slow acetylators of isoniazid appear to have a higher incidence of some adverse effects. Also, patients whose nutrition is poor are at risk of peripheral neuritis which is one of the commonest adverse effects of isoniazid. Other neurological adverse effects include psychotic reactions and convulsions. Pyridoxine may be given to prevent or treat these adverse effects. Optic neuritis has also been reported. Haematological effects reported following use of isoniazid include various anaemias, agranulocytosis, thrombocytopenia and eosinophilia.
NATRICIN FORTE DOES NOT CONTAIN SODIUM METABISULFITE
CAUTION:
Food, Drugs, Devices and Cosmetics Act prohibits dispensing without prescription.
DOSAGE AND ADMINISTRATION:
Kidz Kit 3 is indicated for the initial 8-weeks (2 months) phase of short course anti-tuberculosis treatment.
Usual dose for both children and adult:
Pyrazinamide (Zcure) suspension:
25mg per kg body weight daily maximum
daily dose is 3g
Rifampicin (Natricin Forte) suspension:
10mg per kg body weight with a daily
maximum dose of 600mg
Isoniazid + Pyridoxine Hydrochloride (Curazid forte) syrup: 5 mg per kg body
weight with daily maximum dose of 300mg
AVAILABILITY:
A box of Kidz Kit 3 contains:
2 - 120mL bottles of Pyrazinamide (Zcure) suspension
1 - 120mL bottle of Rifampicin (Natricin Forte) suspension
1 - 120mL bottle of Isoniazid + Pyridoxine Hydrochloride (Curazid forte) syrup
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